Invented a more accurate method of gene editing

Scientists at Yale University reported on the creation of a more accurate and effective technology for editing the genome of living organisms. The new method allows you to get rid of the shortcomings of modern technologies, including - CRISPR / Cas9.

"The existing technology can be compared to a saw, and this method - with a scalpel that allows you to make precise genetic changes with high efficiency in a lot of places in the eukaryote genome," says Farren Isaacs.

Modern gene-editing technologies, for example, CRISPR / Cas9, usually break two DNA strands when when genetic changes are being implemented. In order to repair the chain, the body makes efforts that can be lethal for the cell. However, sometimes these gaps remain unresolved or create tiny errors in the DNA sequence that change their functions.

A team of scientists from Yale has thus managed to replicate the  DNA yeasts, which made it possible to introduce new genetic information without large discontinuities of the double helix. The technology of eukaryotic multiple gene editing  will speed up the replacement of pathogenic genes, the search  and development of natural antibiotics or anti-cancer agents and will spur the creation of new biotechnological substances, says Aizkes. He and his group intend to explore new technology in application to multicellular organisms.

A similar statement about the creation of a simpler and more effective gene editing method was made in August by the start-up Homology Medicines. The company claims to have found a way to edit genes without using nuclease, that is, without cutting DNA strands.